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Synaptotagmin IV is necessary for the maturation of secretory granules in PC12 cells
In neuroendocrine PC12 cells, immature secretory granules (ISGs) mature through homotypic fusion and membrane remodeling. We present evidence that the ISG-localized synaptotagmin IV (Syt IV) is involved in ISG maturation. Using an in vitro homotypic fusion assay, we show that the cytoplasmic domain...
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| Autors principals: | , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
The Rockefeller University Press
2006
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2063815/ https://ncbi.nlm.nih.gov/pubmed/16618809 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200506163 |
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