CHMP5 is essential for late endosome function and down-regulation of receptor signaling during mouse embryogenesis

Charged MVB protein 5 (CHMP5) is a coiled coil protein homologous to the yeast Vps60/Mos10 gene and other ESCRT-III complex members, although its precise function in either yeast or mammalian cells is unknown. We deleted the CHMP5 gene in mice, resulting in a phenotype of early embryonic lethality,...

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Detalhes bibliográficos
Main Authors: Shim, Jae-Hyuck, Xiao, Changchun, Hayden, Matthew S., Lee, Ki-Young, Trombetta, E. Sergio, Pypaert, Marc, Nara, Atsuki, Yoshimori, Tamotsu, Wilm, Bettina, Erdjument-Bromage, Hediye, Tempst, Paul, Hogan, Brigid L.M., Mellman, Ira, Ghosh, Sankar
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2006
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2063762/
https://ncbi.nlm.nih.gov/pubmed/16567502
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200509041
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