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p53 functions as a negative regulator of osteoblastogenesis, osteoblast-dependent osteoclastogenesis, and bone remodeling
p53 is a well known tumor suppressor. We show that p53 also regulates osteoblast differentiation, bone formation, and osteoblast-dependent osteoclast differentiation. Indeed, p53 (−) (/) (−) mice display a high bone mass phenotype, and p53 (−) (/) (−) osteoblasts show accelerated differentiation, se...
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| Main Authors: | , , , , , , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
The Rockefeller University Press
2006
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2063539/ https://ncbi.nlm.nih.gov/pubmed/16380437 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200507106 |
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