p53 functions as a negative regulator of osteoblastogenesis, osteoblast-dependent osteoclastogenesis, and bone remodeling

p53 is a well known tumor suppressor. We show that p53 also regulates osteoblast differentiation, bone formation, and osteoblast-dependent osteoclast differentiation. Indeed, p53 (−) (/) (−) mice display a high bone mass phenotype, and p53 (−) (/) (−) osteoblasts show accelerated differentiation, se...

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Bibliographic Details
Main Authors: Wang, Xueying, Kua, Hui-Yi, Hu, Yuanyu, Guo, Ke, Zeng, Qi, Wu, Qiang, Ng, Huck-Hui, Karsenty, Gerard, de Crombrugghe, Benoit, Yeh, James, Li, Baojie
Format: Artigo
Language:Inglês
Published: The Rockefeller University Press 2006
Subjects:
Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2063539/
https://ncbi.nlm.nih.gov/pubmed/16380437
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200507106
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