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Vinculin binding in its closed conformation by a helix addition mechanism
Vinculin links integrin receptors to the actin cytoskeleton by binding to talin. Vinculin is held in an inactive, closed-clamp conformation through hydrophobic interactions between its head and tail domains, and vinculin activation has long been thought to be dependent upon severing the head–tail in...
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| Hauptverfasser: | , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Nature Publishing Group
2007
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2063484/ https://ncbi.nlm.nih.gov/pubmed/17932491 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601863 |
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