Reversal of P-glycoprotein-mediated multidrug resistance by XR9051, a novel diketopiperazine derivative.

XR9051 (N-(4-(2-(6,7-Dimethoxy-1,2,3,4-tetrahydro-2-isoquinolyl)ethyl)phe nyl)-3-((3Z,6Z)-6-benzylidene-1-methyl-2,5-dioxo-3-pipera zinylidene) methylbenzamide) was identified as a potent modulator of P-glycoprotein-mediated multidrug resistance (MDR) following a synthetic chemistry programme based...

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Bibliografiske detaljer
Main Authors: Dale, I. L., Tuffley, W., Callaghan, R., Holmes, J. A., Martin, K., Luscombe, M., Mistry, P., Ryder, H., Stewart, A. J., Charlton, P., Twentyman, P. R., Bevan, P.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group|1 1998
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2063130/
https://ncbi.nlm.nih.gov/pubmed/9764579
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