Biochemical modifications of avidin improve pharmacokinetics and biodistribution, and reduce immunogenicity.

Pretargeting techniques using the avidin-biotin system have shown encouraging results in both diagnostic and therapeutic clinical trials. It has been shown that in cancer therapy the ideal agent to be used for pretargeting should have a plasma half-life longer than avidin and lower immunogenicity th...

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Main Authors: Chinol, M., Casalini, P., Maggiolo, M., Canevari, S., Omodeo, E. S., Caliceti, P., Veronese, F. M., Cremonesi, M., Chiolerio, F., Nardone, E., Siccardi, A. G., Paganelli, G.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group|1 1998
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2062912/
https://ncbi.nlm.nih.gov/pubmed/9683292
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