Do DEAD-Box Proteins Promote Group II Intron Splicing Without Unwinding RNA?

The DEAD-box protein Mss116p promotes group II intron splicing in vivo and in vitro. Here we explore two hypotheses for how Mss116p promotes group II intron splicing: by using its RNA unwinding activity to act as an RNA chaperone or by stabilizing RNA folding intermediates. We show that an Mss116p m...

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Bibliographische Detailangaben
Hauptverfasser: Campo, Mark Del, Tijerina, Pilar, Bhaskaran, Hari, Mohr, Sabine, Yang, Quansheng, Jankowsky, Eckhard, Russell, Rick, Lambowitz, Alan M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2007
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2062517/
https://ncbi.nlm.nih.gov/pubmed/17936712
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2007.07.028
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