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P(1),P(4)-Dithio-P(2),P(3)-monochloromethylene diadenosine 5′,5‴-P(1),P(4)-tetraphosphate: A novel antiplatelet agent

We have previously demonstrated in a series of searches for antithrombotic agents that diadenosine 5′,5‴-P(1),P(4)-tetraphosphate (AppppA) and its analogues are competitive inhibitors of ADP-induced platelet aggregation. Among various analogues, the P(2),P(3)-monochloromethylene analog of AppppA (Ap...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Chan, Samuel W., Gallo, Steven J., Kim, Byung K., Guo, Mao J., Blackburn, G. Michael, Zamecnik, Paul C.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1997
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC20563/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9108100/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.94.8.4034
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