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Antileukemia effect of c-myc N3′→P5′ phosphoramidate antisense oligonucleotides in vivo
In vitro, uniformly modified oligonucleotide N3′→P5′ phosphoramidates are apparently more potent antisense agents than phosphorothioate derivatives. To determine whether such compounds are also effective in vivo, severe combined immunodeficiency mice injected with HL-60 myeloid leukemia cells were t...
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| Main Authors: | , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
The National Academy of Sciences of the USA
1997
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC20551/ https://ncbi.nlm.nih.gov/pubmed/9108088 |
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