Antileukemia effect of c-myc N3′→P5′ phosphoramidate antisense oligonucleotides in vivo

In vitro, uniformly modified oligonucleotide N3′→P5′ phosphoramidates are apparently more potent antisense agents than phosphorothioate derivatives. To determine whether such compounds are also effective in vivo, severe combined immunodeficiency mice injected with HL-60 myeloid leukemia cells were t...

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Dades bibliogràfiques

Publicat a:	Proc Natl Acad Sci U S A
Autors principals:	Skorski, Tomasz, Perrotti, Danilo, Nieborowska-Skorska, Malgorzata, Gryaznov, Sergei, Calabretta, Bruno
Format:	Artigo
Idioma:	Inglês
Publicat:	National Academy of Sciences 1997
Matèries:	Biological Sciences
Accés en línia:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC20551/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9108088/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.94.8.3966
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