Antileukemia effect of c-myc N3′→P5′ phosphoramidate antisense oligonucleotides in vivo
In vitro, uniformly modified oligonucleotide N3′→P5′ phosphoramidates are apparently more potent antisense agents than phosphorothioate derivatives. To determine whether such compounds are also effective in vivo, severe combined immunodeficiency mice injected with HL-60 myeloid leukemia cells were t...
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| 出版年: | Proc Natl Acad Sci U S A |
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| 主要な著者: | , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
National Academy of Sciences
1997
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC20551/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9108088/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.94.8.3966 |
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