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Oxidative stress mediates impairment of muscle function in transgenic mice with elevated level of wild-type Cu/Zn superoxide dismutase

Cases of familial amyotrophic lateral sclerosis (fALS; a neurodegenerative disorder) have been reported in which the gene for Cu/Zn superoxide dismutase (CuZnSOD) was mutated. Several studies with the fALS mutant CuZnSOD in transgenic mice and cells showed that the fALS mutations act through an as y...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Peled-Kamar, M., Lotem, J., Wirguin, I., Weiner, L., Hermalin, A., Groner, Y.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 1997
Témata:
On-line přístup:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC20536/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9108073/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.94.8.3883
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