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Ablation of a small transmembrane protein of Trypanosoma brucei (TbVTC1) involved in the synthesis of polyphosphate alters acidocalcisome biogenesis and function, and leads to a cytokinesis defect

Inorganic poly P (polyphosphate) is an abundant component of acidocalcisomes of Trypanosoma brucei. In the present study we report the presence of a protein homologous with the yeast Vtc1p (vacuolar transporter chaperone 1) in T. brucei that is essential for poly P synthesis, acidocalcisome biogenes...

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Bibliografske podrobnosti
Main Authors: Fang, Jianmin, Rohloff, Peter, Miranda, Kildare, Docampo, Roberto
Format: Artigo
Jezik:Inglês
Izdano: Portland Press Ltd. 2007
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2049025/
https://ncbi.nlm.nih.gov/pubmed/17635107
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20070612
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