Isolation and characterization of monoclonal antibodies elicited by trimeric HIV-1 Env gp140 protein immunogens

Eleven anti-HIV Env monoclonal antibodies (MAbs) were isolated from mice immunized with soluble Env proteins derived from the clade B Env, SF162, or ΔV2 (a derivative of SF162 lacking the V2 loop). All six anti-gp120 MAbs studied, neutralized SF162 and their activities were dependent by the glycosyl...

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Bibliografiske detaljer
Main Authors:	Derby, Nina R., Gray, Sean, Wayner, Elizabeth, Campogan, Dwayne, Vlahogiannis, Giorgos, Kraft, Zane, Barnett, Susan W., Srivastava, Indresh K., Stamatatos, Leonidas
Format:	Artigo
Sprog:	Inglês
Udgivet:	2007
Fag:	Article
Online adgang:	https://ncbi.nlm.nih.gov/pmc/articles/PMC2048818/ https://ncbi.nlm.nih.gov/pubmed/17560621 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2007.05.020
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Isolation and characterization of monoclonal antibodies elicited by trimeric HIV-1 Env gp140 protein immunogens

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