Characterization of the interaction between DARPP-32 and protein phosphatase 1 (PP-1): DARPP-32 peptides antagonize the interaction of PP-1 with binding proteins

The catalytic subunit of PP-1 (PP-1C) is potently inhibited (IC(50), ≈1 nM) by DARPP-32 (dopamine- and cAMP-regulated phosphoprotein, M(r) 32,000), inhibitor-1, and inhibitor-2. The NH(2)-terminal 50 amino acid residues of DARPP-32 and inhibitor-1 are similar, and phosphorylation of a common threoni...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Kwon, Young-Guen, Huang, Hsien-Bin, Desdouits, Frédéric, Girault, Jean-Antoine, Greengard, Paul, Nairn, Angus C.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1997
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC20474/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9108011/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.94.8.3536
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