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Mechanism of Actin Network Attachment to Moving Membranes: Barbed End Capture by N-WASP WH2 Domains

Actin filament networks exert protrusive and attachment forces on membranes and thereby drive membrane deformation and movement. Here, we show that N-WASP WH2 domains play a previously unanticipated role in vesicle movement by transiently attaching actin filament barbed ends to the membrane. To diss...

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Autori principali: Co, Carl, Wong, Derek T., Gierke, Sarah, Chang, Vicky, Taunton, Jack
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2007
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2047291/
https://ncbi.nlm.nih.gov/pubmed/17350575
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2006.12.049
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