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Preferential Integration of Adeno-Associated Virus Type 2 into a Polypyrimidine/Polypurine-Rich Region within AAVS1
Adeno-associated virus type 2 (AAV2) preferentially integrates its genome into the AAVS1 locus on human chromosome 19. Preferential integration requires the AAV2 Rep68 or Rep78 protein (Rep68/78), a Rep68/78 binding site (RBS), and a nicking site within AAVS1 and may also require an RBS within the v...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Microbiology
2007
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2045435/ https://ncbi.nlm.nih.gov/pubmed/17626070 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00746-07 |
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