Severe Acute Respiratory Syndrome Coronavirus ORF6 Antagonizes STAT1 Function by Sequestering Nuclear Import Factors on the Rough Endoplasmic Reticulum/Golgi Membrane

The host innate immune response is an important deterrent of severe viral infection in humans and animals. Nuclear import factors function as key gatekeepers that regulate the transport of innate immune regulatory cargo to the nucleus of cells to activate the antiviral response. Using severe acute r...

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Detalles Bibliográficos
Main Authors: Frieman, Matthew, Yount, Boyd, Heise, Mark, Kopecky-Bromberg, Sarah A., Palese, Peter, Baric, Ralph S.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2007
Assuntos:
Cellular Response to Infection
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2045396/
https://ncbi.nlm.nih.gov/pubmed/17596301
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01012-07
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