Mutations in Residues Involved in Zinc Binding in the Catalytic Site of Escherichia coli Threonyl-tRNA Synthetase Confer a Dominant Lethal Phenotype

Escherichia coli threonyl-tRNA synthetase is a homodimeric protein that acts as both an enzyme and a regulator of gene expression: the protein aminoacylates tRNA(Thr) isoacceptors and binds to its own mRNA, inhibiting its translation. The enzyme contains a zinc atom in its active site, which is esse...

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Bibliographic Details
Main Authors: Caillet, Joël, Graffe, Monique, Eyermann, Flore, Romby, Pascale, Springer, Mathias
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2007
Subjects:
Enzymes and Proteins
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2045194/
https://ncbi.nlm.nih.gov/pubmed/17644600
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JB.00439-07
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