Genetic Alteration of Mycobacterium smegmatis To Improve Mycobacterium-Mediated Transfer of Plasmid DNA into Mammalian Cells and DNA Immunization

Mycobacteria target and persist within phagocytic monocytes and are strong adjuvants, making them attractive candidate vectors for DNA vaccines. We characterized the ability of mycobacteria to deliver transgenes to mammalian cells and the effects of various bacterial chromosomal mutations on the eff...

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Detalhes bibliográficos
Main Authors: Mo, Yongkai, Quanquin, Natalie M., Vecino, William H., Ranganathan, Uma Devi, Tesfa, Lydia, Bourn, William, Derbyshire, Keith M., Letvin, Norman L., Jacobs, William R., Fennelly, Glenn J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2007
Assuntos:
Microbial Immunity and Vaccines
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2044538/
https://ncbi.nlm.nih.gov/pubmed/17664267
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.01877-06
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