Genetic Alteration of Mycobacterium smegmatis To Improve Mycobacterium-Mediated Transfer of Plasmid DNA into Mammalian Cells and DNA Immunization

Mycobacteria target and persist within phagocytic monocytes and are strong adjuvants, making them attractive candidate vectors for DNA vaccines. We characterized the ability of mycobacteria to deliver transgenes to mammalian cells and the effects of various bacterial chromosomal mutations on the eff...

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Détails bibliographiques
Auteurs principaux: Mo, Yongkai, Quanquin, Natalie M., Vecino, William H., Ranganathan, Uma Devi, Tesfa, Lydia, Bourn, William, Derbyshire, Keith M., Letvin, Norman L., Jacobs, William R., Fennelly, Glenn J.
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology 2007
Sujets:
Microbial Immunity and Vaccines
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2044538/
https://ncbi.nlm.nih.gov/pubmed/17664267
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.01877-06
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