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Analysis of anomalous pKB values for metiamide and atropine in the isolated stomach of the mouse

1 In the isolated, lumen-perfused, stomach preparation of the mouse, metiamide was found by kinetic analysis to behave like a simple competitive antagonist of histamine-stimulated acid secretion. However, the pK(B) estimate of 5.08 was significantly lower than that found in guinea-pig atrium (6.0) o...

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Detalhes bibliográficos
Main Authors: Angus, J.A., Black, J.W.
Formato: Artigo
Idioma:Inglês
Publicado em: 1979
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2043596/
https://ncbi.nlm.nih.gov/pubmed/497522
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