Plasmid-Encoded ACC-4, an Extended-Spectrum Cephalosporinase Variant from Escherichia coli

ACC-4, an omega loop mutant (Val(211)→Gly) of the Hafnia alvei-derived cephalosporinase ACC-1, was encoded by an Escherichia coli plasmid. The genetic environment of bla(ACC-4) shared similarities with plasmidic regions carrying bla(ACC-1). Kinetics of β-lactam hydrolysis and levels of resistance to...

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Bibliographic Details
Main Authors: Papagiannitsis, Costas C., Tzouvelekis, Leonidas S., Tzelepi, Eva, Miriagou, Vivi
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2007
Subjects:
Mechanisms of Resistance
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2043296/
https://ncbi.nlm.nih.gov/pubmed/17664321
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00389-07
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