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The Antifungal Polyketide Ambruticin Targets the HOG Pathway
The polyketide ambruticin is an attractive candidate for drug development as an antifungal agent, but its mechanism of action has not yet been elucidated. Here we present evidence that ambruticin exerts its effect by targeting HOG, the osmotic stress control pathway, through Hik1, a group III histid...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Microbiology
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2043265/ https://ncbi.nlm.nih.gov/pubmed/17698623 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00369-07 |
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