Pulmonary versus Systemic Delivery of Antibiotics: Comparison of Vancomycin Dispositions in the Isolated Rat Lung

Vancomycin dispositions in the respiratory system were compared after systemic and inhalatory administration under two respiratory conditions using the isolated-lung model. Inhalatory delivery led to much higher drug levels in pulmonary tissue and fluids. The respiratory pattern affects vancomycin d...

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Main Authors: de Jesús Valle, María José, López, Francisco González, Hurlé, Alfonso Domínguez-Gil, Navarro, Amparo Sánchez
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2007
Fag:
Experimental Therapeutics
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2043261/
https://ncbi.nlm.nih.gov/pubmed/17682107
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00099-07
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