Pharmacokinetics of Aztreonam in Healthy Subjects and Patients with Cystic Fibrosis and Evaluation of Dose-Exposure Relationships Using Monte Carlo Simulation

Aztreonam (AZM) is a monobactam antibiotic with a high level of activity against gram-negative micro-organisms, including Pseudomonas aeruginosa. We evaluated AZM pharmacokinetics and pharmacokinetic-pharmacodynamic relationships in patients with cystic fibrosis (CF) and healthy subjects. Pharmacoki...

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Main Authors: Vinks, Alexander A., van Rossem, Ronald N., Mathôt, Ron A. A., Heijerman, Harry G. M., Mouton, Johan W.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2007
Teme:
Pharmacology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2043218/
https://ncbi.nlm.nih.gov/pubmed/17576827
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01522-06
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