The peptidase inhibitor CGS-26303 increases endothelin converting enzyme-1 expression in endothelial cells through accumulation of big endothelin-1

BACKGROUND AND PURPOSE: CGS-26303 inhibits endothelin converting enzyme (ECE)-1 more specifically than phosphoramidon. We have studied the effect of CGS-26303 on ECE-1 expression in bovine aortic endothelial cells. METHODS: ECE-1 activity and big endothelin (ET)-1 levels were measured by ELISA, ECE-...

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Hlavní autoři: Raoch, V, Martinez-Miguel, P, Arribas-Gomez, I, Rodriguez-Puyol, M, Rodriguez-Puyol, D, Lopez-Ongil, S
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2007
Témata:
Research Papers
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2042959/
https://ncbi.nlm.nih.gov/pubmed/17643133
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0707398
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