Integrated pharmacokinetics and pharmacodynamics of Ro 48–8684, a new benzodiazepine, in comparison with midazolam during first administration to healthy male subjects

Aims This study aimed to investigate the pharmacodynamics and pharmacokinetics of ascending doses of Ro 48–8684, compared with midazolam, in healthy subjects during first administration to man. Methods The study was double-blind and five-way crossover (three ascending doses, placebo, fixed midazolam...

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Detalhes bibliográficos
Main Authors: van Gerven, J. M. A., Roncari, G., Schoemaker, R. C., Massarella, J., Keesmaat, P., Kooyman, H., Heizmann, P., Zell, M., Cohen, A. F., Dingemanse, J.
Formato: Artigo
Idioma:Inglês
Publicado em: 1997
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2042863/
https://ncbi.nlm.nih.gov/pubmed/9384466
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2125.1997.t01-1-00613.x
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