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Involvement of CYP2D6 but not CYP2C19 in nicergoline metabolism in humans
1Nicergoline, an ergot derivative previously used as a vasodilator, has gained a new indication in treating the symptoms of senile dementia. 2Nicergoline is rapidly hydrolysed to an alcohol derivative, 1-methyl-10-α-methoxy-9,10-dihydrolysergol (MMDL), which is further N-demethylated to form 10-α-me...
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| Main Authors: | , , , , , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
1996
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2042720/ https://ncbi.nlm.nih.gov/pubmed/8971425 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2125.1996.00471.x |
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