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Pharmacodynamics of oxypurinol after administration of allopurinol to healthy subjects

1 Eight healthy subjects received 50, 100, 300, 600 and 900 mg allopurinol daily for 1 week each, in random order with 1 week separating each treatment period. The pre-dose plasma concentration of oxypurinol, the extent of inhibition of xanthine oxidase, plasma urate concentration and urine urate ex...

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Detalhes bibliográficos
Main Authors: GRAHAM, S., DAY, R. O., WONG, H., McLACHLAN, A. J., BERGENDAL, L., MINERS, J. O., BIRKETT, D. J.
Formato: Artigo
Idioma:Inglês
Publicado em: 1996
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2042594/
https://ncbi.nlm.nih.gov/pubmed/8730975
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2125.1996.03116.x
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