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The influence of the sparteine/debrisoquine genetic polymorphism on the disposition of dexfenfluramine
1 To determine whether dexfenfluramine is a substrate of cytochrome P450 2D6 (CYP2D6), its disposition has been studied in nine extensive (EM) and eight poor metabolizers (PM) of debrisoquine. 2 Following a 30 mg dose of dexfenfluramine hydrochloride, urine was collected in all subjects for 96 h pos...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
1996
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2042591/ https://ncbi.nlm.nih.gov/pubmed/8730977 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2125.1996.03178.x |
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