Optimizing the protein switch: altering nuclear import and export signals, and ligand binding domain

Ligand regulated localization controllable protein constructs were optimized in this study. Several constructs were made from a classical nuclear export signal (HIV-rev, MAPKK, or progesterone receptor) in combination with a SV40 T-antigen type nuclear import signal. Different ligand binding domains...

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Bibliographic Details
Main Authors: Kakar, Mudit, Davis, James R., Kern, Steve E., Lim, Carol S.
Format: Artigo
Language:Inglês
Published: 2007
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2041942/
https://ncbi.nlm.nih.gov/pubmed/17574289
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jconrel.2007.04.017
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