Induction of Cullin 7 by DNA damage attenuates p53 function

The p53 tumor suppressor gene encodes a transcription factor, which is translationally and posttranslationally activated after DNA damage. In a proteomic screen for p53 interactors, we found that the cullin protein Cul7 efficiently associates with p53. After DNA damage, the level of Cul7 protein inc...

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Autori principali: Jung, Peter, Verdoodt, Berlinda, Bailey, Aaron, Yates, John R., Menssen, Antje, Hermeking, Heiko
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2007
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2040908/
https://ncbi.nlm.nih.gov/pubmed/17586686
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0609467104
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