PapA1 and PapA2 are acyltransferases essential for the biosynthesis of the Mycobacterium tuberculosis virulence factor Sulfolipid-1

Mycobacterium tuberculosis produces numerous exotic lipids that have been implicated as virulence determinants. One such glycolipid, Sulfolipid-1 (SL-1), consists of a trehalose-2-sulfate (T2S) core acylated with four lipid moieties. A diacylated intermediate in SL-1 biosynthesis, SL(1278), has been...

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Detalhes bibliográficos
Main Authors: Kumar, Pawan, Schelle, Michael W., Jain, Madhulika, Lin, Fiona L., Petzold, Christopher J., Leavell, Michael D., Leary, Julie A., Cox, Jeffery S., Bertozzi, Carolyn R.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2007
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2040880/
https://ncbi.nlm.nih.gov/pubmed/17592143
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0611649104
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