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Measurement of 7,8-dihydro-8-oxo-2′-deoxyguanosine metabolism in MCF-7 cells at low concentrations using accelerator mass spectrometry
Growing evidence suggests that oxidative damage to cells generates mutagenic 7,8-dihydro-8-oxo-2′-deoxyguanosine (8-oxodG), which may initiate diseases related to aging and carcinogenesis. Kinetic measurement of 8-oxodG metabolism and repair in cells has been hampered by poor assay sensitivity and b...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2040877/ https://ncbi.nlm.nih.gov/pubmed/17592118 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0701733104 |
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