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Potent D-peptide inhibitors of HIV-1 entry

During HIV-1 entry, the highly conserved gp41 N-trimer pocket region becomes transiently exposed and vulnerable to inhibition. Using mirror-image phage display and structure-assisted design, we have discovered protease-resistant D-amino acid peptides (D-peptides) that bind the N-trimer pocket with h...

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Hlavní autoři: Welch, Brett D., VanDemark, Andrew P., Heroux, Annie, Hill, Christopher P., Kay, Michael S.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2007
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2040420/
https://ncbi.nlm.nih.gov/pubmed/17942675
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0708109104
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