Valsartan lowers brain β-amyloid protein levels and improves spatial learning in a mouse model of Alzheimer disease

Recent epidemiological evidence suggests that some antihypertensive medications may reduce the risk for Alzheimer disease (AD). We screened 55 clinically prescribed antihypertensive medications for AD-modifying activity using primary cortico-hippocampal neuron cultures generated from the Tg2576 AD m...

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Autori principali: Wang, Jun, Ho, Lap, Chen, Linghong, Zhao, Zhong, Zhao, Wei, Qian, Xianjuan, Humala, Nelson, Seror, Ilana, Bartholomew, Sadie, Rosendorff, Clive, Pasinetti, Giulio Maria
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2007
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2040315/
https://ncbi.nlm.nih.gov/pubmed/17965777
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI31547
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