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RAPAMYCIN REGULATES THE PHOSPHORYLATION OF RICTOR
The mammalian target of rapamycin (mTOR) is a central regulator of cell growth. mTOR exists in two functional complexes, mTORC1 and mTORC2. mTORC1 is rapamycin-sensitive, and results in phosphorylation of 4E-BP1 and S6K1. mTORC2 is proposed to regulate Akt Ser473 phosphorylation and be rapamycin-ins...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2007
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2040311/ https://ncbi.nlm.nih.gov/pubmed/17707343 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2007.07.15 |
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