Noxa/Mcl-1 Balance Regulates Susceptibility of Cells to Camptothecin-Induced Apoptosis

Although camptothecin (CPT) has been reported to induce apoptosis in various cancer cells, the molecular details of this regulation remain largely unknown. In this study, we demonstrate that BH3-only protein Noxa is upregulated during CPT-induced apoptosis, which is independent of p53. In addition,...

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Main Authors: Mei, Yide, Xie, Chongwei, Xie, Wei, Tian, Xu, Li, Mei, Wu, Mian
Formato: Artigo
Idioma:Inglês
Publicado: Neoplasia Press Inc. 2007
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2040214/
https://ncbi.nlm.nih.gov/pubmed/17971907
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