A Mutant Ataxin-3 Fragment Results From Processing at a Site N-terminal to Amino Acid 190 in Brain of Machado-Joseph Disease-Like Transgenic Mice

Machado Joseph disease also called spinocerebellar ataxia type 3 (MJD/SCA3) is a hereditary and neurodegenerative movement disorder caused by ataxin-3 with a polyglutamine expansion (mutant ataxin-3). Neuronal loss in MJD/SCA3 is associated with a mutant ataxin-3 toxic fragment. Defining mutant atax...

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Bibliographische Detailangaben
Hauptverfasser: Colomer Gould, Veronica F., Goti, Daniel, Pearce, Donna, Gonzalez, Guillermo A., Gao, Hong, de Leon, Mario Bermudez, Jenkins, Nancy A., Copeland, Neal G., Ross, Christopher A., Brown., Dale R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2007
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2040168/
https://ncbi.nlm.nih.gov/pubmed/17632007
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2007.06.005
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