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Ethanol acts directly on extrasynaptic subtypes of GABA(A) receptors to increase tonic inhibition

Based on the similarity of ethanol intoxication to the behavioral effects of drugs known to target GABA(A) receptors (GABARs) it has been suspected for decades that ethanol facilitates the activity of GABA. Even so, it has been surprisingly difficult to identify molecular targets of ethanol. Researc...

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Autori principali: Santhakumar, Vijayalakshmi, Wallner, Martin, Otis, Thomas S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2007
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2040048/
https://ncbi.nlm.nih.gov/pubmed/17591544
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.alcohol.2007.04.011
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