Adenoviral transfer of mda-7 leads to BAX up-regulation and apoptosis in mesothelioma cells, and is abrogated by over-expression of BCL-XL.

BACKGROUND: Malignant pleural mesothelioma (MPM) is unresponsive to conventional therapies. Forced expression of the novel tumor suppressor mda-7 gene in other cell types has resulted in decreased growth and apoptosis. We evaluated cell growth, apoptosis and tumor suppressor characteristics followin...

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Autores principales: Cao, Xiaobo X., Mohuiddin, Imran, Chada, Sunil, Mhashilkar, Abner M., Ozvaran, Mustafa K., McConkey, David J., Miller, Steven D., Daniel, Jonathon C., Smythe, W. Roy
Formato: Artigo
Lenguaje:Inglês
Publicado: 2002
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2039963/
https://ncbi.nlm.nih.gov/pubmed/12606823
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