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Overexpression of the Shb SH2 domain-protein in insulin-producing cells leads to altered signaling through the IRS-1 and IRS-2 proteins.

BACKGROUND: Overexpression of the Src homology 2 domain protein Shb in beta-cells of transgenic mice has been shown to promote an increased beta-cell mass. To investigate the mechanisms by which Shb controls the beta-cell mass, we have presently studied the effects of Shb overexpression on the IRS-1...

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Hlavní autoři: Welsh, Nils, Makeeva, Natalia, Welsh, Michael
Médium: Artigo
Jazyk:Inglês
Vydáno: 2002
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2039954/
https://ncbi.nlm.nih.gov/pubmed/12520086
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