The progression in the mouse skin carcinogenesis model correlates with ERK1/2 signaling.

BACKGROUND: The ras family of proto-oncogenes encodes for small GTPases that play critical roles in cell-cycle progression and cellular transformation. ERK1/2 MAP kinases are major ras effectors. Tumors in chemically treated mouse skin contain mutations in the Ha-ras proto- oncogene. Amplification a...

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Main Authors: Katsanakis, Kostas D., Gorgoulis, Vassilis, Papavassiliou, Athanasios G., Zoumpourlis, Vassilis K.
Format: Artigo
Jezik:Inglês
Izdano: 2002
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2039942/
https://ncbi.nlm.nih.gov/pubmed/12477973
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