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Anti HIV-1 Virucidal Activity of Polyamide Nucleic Acid-Membrane Transducing Peptide Conjugates Targeted to Primer Binding Site of HIV-1 Genome
We have shown that polyamide nucleic acids (PNAs) targeted to the PBS (PNA(PBS)) and A-loop (PNA(A-loop)) sequences, when transfected into cells, inhibit HIV-1 replication by blocking the initiation of reverse transcription via destabilizing tRNA(3)(Lys) primer from the viral genome. Here we demonst...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2007
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2038983/ https://ncbi.nlm.nih.gov/pubmed/17320140 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2007.01.016 |
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