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Age-dependent decrease of synaptic plasticity in the neocortex of αCaMKII mutant mice

Synaptic long-term potentiation (LTP) and long-term depression (LTD) were studied in the visual cortex of mutant mice lacking α-calcium/calmodulin-dependent protein kinase II (αCaMKII). In adult mutants, little LTD or LTP could be elicited using standard conditioning protocols. However, substantial...

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Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Kirkwood, Alfredo, Silva, Alcino, Bear, Mark F.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 1997
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Accesso online:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC20378/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9096402/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.94.7.3380
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