Human lymphotoxin mutein lacks hypotensive activity but has higher in vivo antitumor activity than lymphotoxin or tumor necrosis factor
A serious drawback of tumor necrosis factor α (TNF) as a clinical antitumor agent is that it also has hypotensive activity. To overcome this problem, derivatives of its sister cytokine lymphotoxin (TNF-β or LT) were prepared. One of them, mutein 2 (Mut2) has a deletion of amino acids 1–7 but contain...
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| Publicat a: | Proc Natl Acad Sci U S A |
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| Autors principals: | , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
National Academy of Sciences
1997
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC20368/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9096392/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.94.7.3324 |
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