Human lymphotoxin mutein lacks hypotensive activity but has higher in vivo antitumor activity than lymphotoxin or tumor necrosis factor

A serious drawback of tumor necrosis factor α (TNF) as a clinical antitumor agent is that it also has hypotensive activity. To overcome this problem, derivatives of its sister cytokine lymphotoxin (TNF-β or LT) were prepared. One of them, mutein 2 (Mut2) has a deletion of amino acids 1–7 but contain...

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Publicado en:	Proc Natl Acad Sci U S A
Autores principales:	Taniyama, Mitsue, Morita, Toshimi, Yamagishi, Yasuhiro, Kato, Akihisa, Bando, Chinami, Okawa, Noriyuki, Kaji, Akira
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	National Academy of Sciences 1997
Materias:	Biological Sciences
Acceso en línea:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC20368/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9096392/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.94.7.3324
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