Folate deficiency causes uracil misincorporation into human DNA and chromosome breakage: Implications for cancer and neuronal damage

Folate deficiency causes massive incorporation of uracil into human DNA (4 million per cell) and chromosome breaks. The likely mechanism is the deficient methylation of dUMP to dTMP and subsequent incorporation of uracil into DNA by DNA polymerase. During repair of uracil in DNA, transient nicks are...

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Detalhes bibliográficos
Main Authors: Blount, Benjamin C., Mack, Matthew M., Wehr, Carol M., MacGregor, James T., Hiatt, Robert A., Wang, Gene, Wickramasinghe, Sunitha N., Everson, Richard B., Ames, Bruce N.
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences of the USA 1997
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC20362/
https://ncbi.nlm.nih.gov/pubmed/9096386
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