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Role of 3-O-sulfated heparan sulfate in virus-induced polykaryocyte formation

One way herpes simplex virus type-1 (HSV-1) spreads in vivo is by polykaryocytes formation. Here we demonstrate that polykaryocyte production during HSV-1 spread in cultured human corneal fibroblasts (CF) required heparan sulfate (HS) and more specifically 3-O sulfated HS (3-OS HS). The polykaryocyt...

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Autors principals: Tiwari, Vaibhav, ten Dam, Gerdy. B., Yue, Beatrice Y.J.T., van Kuppevelt, Toin. H., Shukla, Deepak
Format: Artigo
Idioma:Inglês
Publicat: 2007
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2034492/
https://ncbi.nlm.nih.gov/pubmed/17765228
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.febslet.2007.08.029
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