Improved silencing properties using small internally segmented interfering RNAs

RNA interference is mediated by small interfering RNAs (siRNAs) that upon incorporation into the RNA-induced silencing complex (RISC) can target complementary mRNA for degradation. Standard siRNA design usually feature a 19–27 base pair contiguous double-stranded region that is believed to be import...

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Main Authors: Bramsen, Jesper B., Laursen, Maria B., Damgaard, Christian K., Lena, Suzy W., Ravindra Babu, B., Wengel, Jesper, Kjems, Jørgen
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2007
Fag:
RNA
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2034465/
https://ncbi.nlm.nih.gov/pubmed/17726057
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkm548
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